Amendment 2, and the expanded qualifying medical conditions, became effective on January 3, 2017. The Florida Department of Health, physicians, dispensing organizations, and patients are bound by Article X Section 29 of the Florida Constitution and 381.986 Florida Statutes.
Cannabis or marijuana has been used by humans for thousands of years. The earliest documented association of marijuana with humans appears to be from 27,600 BCE in Czechoslovakia. Starting about 3000 BCE, Chinese Emperors played a key role in the medicinal use of marijuana for gout, malaria and rheumatism. This medicinal use spread to Asia, Middle East and Africa. The Old Testament talks about using marijuana. Physicians used marijuana for practically all ailments with varied success. By the late 18th century American medical journals started to recommend hemp seeds and roots for a variety of diseases. An Irish doctor practicing in India learned the use of marijuana for rheumatism, cholera, rabies and tetanus and popularized it in UK and America.
At the end of the 19th century, it was deemed necessary to reduce the patients addicted to morphine and to switch them to a more benign agent. This led to the creation of FDA in 1906. Marijuana was defined as a drug in 1914 in USA. BY 1937, 23 states outlawed marijuana as illegal for a variety of reasons, including Federal Marijuana tax act, which made the use of non-medical marijuana illegal. The research on medical marijuana switched to Israel in the 1960s and the main active ingredient was identified in 1964 and was found to be THC (Tetrahydrocannabinol). Subsequently, Cannabiodiol (CBD) was found to be the agent offering most help for spasticity, seizures, anxiety and psychosis. The low-THC marijuana is meant to give patient more of CBD and less of THC. Some evidence points to higher efficacy when THC:CBD are used in 1:1 ratio.
There are hundreds of chemical compounds in the cannabis plant that work together to provide relief to a variety of symptoms. These compounds work by imitating compounds our bodies already produce called endocannabinoids. All humans have an endocannabinoid system, the balance of which works to ensure internal stability and health. Cannabinoids help negotiate the communication between cells. When there is a problem with our endocannabinoid system, unpleasant symptoms and complications can occur.
When you consume cannabis, cannabinoids bind to receptors in the nervous system in both the brain (CB-1 receptors) and the body (CB-2 receptors). Different cannabinoids have different effects depending on which receptors they bind to. For example, THC binds to receptors in the brain, while CBN (cannabinol) will typically bind to receptors in the body.